Synaptic consolidation: an approach to long-term learning

Synaptic Learning Rules with Consolidation

How do we remember the past ? By what means can we make sense of our environment and store its most relevant aspects ? Learning and memory is very important for the existence of complex behaviours in living animals since it is what enables the creation of an internal model of the world in order to take the best possible decisions. The theory of synaptic tagging and capture (STC) represents a po...

Consolidation and long-term retention of an implanted behavioral memory.

Hypothesized circuitry enabling information storage can be tested by attempting to implant memory directly in the brain in the absence of normal experience. Previously, we found that tone paired with activation of the cholinergic nucleus basalis (NB) does induce behavioral memory that shares cardinal features with natural memory; it is associative, highly specific, rapidly formed, consolidates ...

Synaptic reentry reinforcement based network model for long-term memory consolidation.

The conversion of newly formed declarative memories into long-term memories is known to be dependent on the hippocampus. Recent experiments suggest that memory consolidation requires reactivation of the NMDA receptor in CA1 during the initial week(s) after training. This led to the hypothesis that the repeated post-learning reinforcement of synaptic modifications, termed synaptic reentry reinfo...

A unifying functional approach towards synaptic long-term plasticity

The Persistence of Long-Term Memory A Molecular Approach to Self-Sustaining Changes in Learning-Induced Synaptic Growth

Recent cellular and molecular studies of both implicit and explicit memory storage suggest that experience-dependent modulation of synaptic strength and structure is a fundamental mechanism by which these diverse forms of memory are encoded and stored. For both forms of memory storage, some type of synaptic growth is thought to represent the stable cellular change that maintains the long-term p...